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  • Embolic Microspheres
Embolic Microspheres 로고
Resorbable Gelatin
Microspheres for
Vascular Embolization
Brochure
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Nexsphere™ is a gelatin based hydrophilic microspheres for endovascular embolizations, that is used together with a contrasting agent during vascular embolization for therapeutic and treatment purposes. It is injected into the blood vessel through a microcatheter in order to temporarily occlude the blood vessel. Nexsphere™ is an resorbable microsphere that exhibits embolic performance in a variety of indications with uniform spherical particles, high elasticity and strong cohesion.

Overview
Indication
  • Use in embolization of blood vessels to occlude blood flow for therapeutic purposes

  • Indication

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Liver Cancer

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Uterine Fibroids

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Prostatic Hyperplasis

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Osteoarthritis

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Arterial Bleeding


Features
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Uniform Spherical Particles

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Minimization of side effects
without crosslinking agents

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Injection container that prevents contamination
Vial designed for contamination prevetion (Design Patent : 3009879200000)

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Various size selections depending
on the patient condition


How to use
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01

Inject saline into the Nexsphere™ vial using a luer lock syringe and then shake to disperse and hydrate the microspheres

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Slowly inject the contrast medium into Nexsphere™ vial with saline using a luer lock syringe, and shake for minutes to mix the contents.

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Transfer the mixed contents to a syringe.

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04

Inject the mixed Nexshpere™ contents into the lesion via a stanard catheter

  • Best practice
  • It is recommended to wait for hydration depending on sizes after adding saline to the Nexsphere™ vial and shaking.

  • Inject contrast medium into the vial containing saline and Nexsphere™

Product highlights
  • Gelatin based resorbable microspheres capable of temporary embolization

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    Nexsphere

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    Gelatin sponge

  • High elasticity and cohesive force1)

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  • Absorbable within 2 hours after embolization 2) 제품로고 이미지

    Histology of Rat Liver 3)

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    Embolization

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    2 hours after embolization

    아이콘Non-resorbable product
    아이콘Non-resorbable product

    Angiography of Porcine Kidney 3)

    Pre-embolization

    Embolization

    Recanalization 2 hours after embolization

  • Effective and safe way to relieve pain and promote functional recovery in patient 4)

    No adverse events including skin discoloration 4)

    Post-marketing clinical trials in progress

    1. - Seoul Asan Medical Center in Korea : A prospective, comparative study is currently ongoing to evaluate safety and efficacy or Nexsphere with different absorbable times for transcatheter arterial chemoembolization for hepatocellular carcinoma. (150 patients)
    2. - Severance Hospital in Korea : Comparison of pain after uterine artery embolization using spherical gelfoam or tris-acryl gelatin microsphere in patients with symptomatic fibroids: A Prospective, Randomized Study. (60 patients)


Preclinical outcomes
porcine kidney embolization 5)
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  • Before
    embolization

  • 5mins after
    embolization

  • 1week after
    embolization

  • 2week after
    embolization

  • 4week after
    embolization

Ordering information
Ordering Code Size
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Quantity
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UIGB 100 100-300 300
UIGB 300 300-500 300
UIGB 500 500-700 300
UIGB 700 700-900 300
Nexsphere-H 100-300 250
Nexsphere-F 100-300 200
References
    1. 1) In-house elasticity and cohesion tests were performed on monolayers of microspheres with a texture analyzer.
    2. 2) In house in-vitro degradation test showed that Nexsphere-F was degraded in 37°C of warm saline within 2 hours.
    3. 3) Animal studies were conducted with Nexsphere-F by external non-clinical CRO in Korea. Animal study results may or may not be indicative of clinical outcomes in humans.
    4. 4) Jae Hwan Lee et al. Short-term Results of Transcatheter Arterial Embolization for Chronic Medical Epicondylitis Refractory to Conservative Treatment : A Single-Center Retrospective Cohort Study. Cardiovasc Intervent Radiol. 2021 June 4.
    5. 5) Animal studies were conducted with Nexsphere by external non-clinical CRO in Korea. Animal study results may or may not be indicative of clinical outcomes in humans.