Innovative Hemostatic Systems for Endoscopy
Just Spray It ! Endoscopic hemostatic system for GI bleeding
Brochure
Nexpowder is a powdery wound dressing for endoscopies made of biocompatible polymer, used for gastrointestinal bleeding.
It is a convenient and safe product that can be used where the bleed is occurring without direct contact to the tissue, regardless of the bleeding location.
Nexpowder is sprayed through the endoscope, and when it comes in contact with water, as well as blood, gelation occurs; physically applying pressure
to the wound to prevent bleeding.
This adhesive gel also protects the wound, prevents contamination, and loss of body fluids that may occur through the wound.
The gel removes itself and is excreted within 1 to 3 days.
Indication
Nexpowder is a product used for wounds and bleeding sites during hemorrhagic digestive ulcers,
endoscopic mucosal resection (EMR), and endoscopic submucosal dissection (ESD) procedures.
Nexpowder prevents contamination of the affected area, protects wounds, and emits a hemostatic effect.
Features
Hemostatic effect
immediately after use
Low rate of re-bleeding
Convenient to use
No precise targeting required
Low rate of clogging
How to use
Best practice
Make sure the valve is closed after connecting the catheter to spray body.
Be sure to turn on the power before inserting the catheter into the endoscope channel.
Do not place the catheter directly in contact with the bleeding site.
Do not aspirate while catheter is in the accessory channel.
Clinical outcomes
Immediate
hemostasis rate1
The adhesive
Force of other
Hemostatic sprays2
Rebleeding
rate3
NexpowderTM has a high success rate for initial hemostasis in refractory upper gastrointestinal bleeding and is effective in prevention of rebleeding1)
Video playInitial hemostasis 16 out of 17 patients (94%).
Rebleeding within 30 days was seen in 3 out of 16 patients (19%)
Remnants of the gel was evident in 11 out of 16 patients (69%) at the second examination after 24 hours.
NexpowderTM can be effective for treatment of nonvariceal upper gastrointestinal bleeding as monotherapy and preventing rebleeding3)
Immediate hemostasis was achieved in 54 of 56 patients (96.4%)
The re-bleeding rate within 30 days was 3.7% (2/54 patients)
No adverse event related to use of Nexpowder occurred.
NexpowderTM is considered an effective salvage therapy or even monotherapy for GI tumor bleeding with high immediate hemostasis and low rebleeding rate4)
Immediate hemostasis occurred in 40 out of 41 patients (97.5%)
Overall rebleeding rates at 7 and 28 days after hemostasis were 7.5% (3 of 40 patients) and 22.5% (9/40 patients)
The initial hemostasis success rate of conventional endoscopic therapy for tumor bleeding ranges from 31~40%
and the short-term rebleeding rate is about 80%.
No adverse event related to use of Nexpowder occurred.
Case videos by Medtronic
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Dr. Beyna's experience with Nexpowder™
Dr. Repici’s experience with Nexpowder™
©2021 Medtronic. All rights reserved. Used with the permission of Medtronic.
Global partnership
Ordering information
* 1 procedure kit
| Product Name | Reference No. | Specifications | Quantity |
|---|---|---|---|
| Nexpowder | UI-EWD3 | 3g | 1ea |
| Catheter | EU-2522 | 2.5mm/220cm | 1ea |
| Spray body | UIPSD04 | 1ea | 1ea |
References
Park JS, Bang BW, Hong SJ, et al. Efficacy of a novel hemostatic adhesive powder in patients with refractory upper gastrointestinal bleeding: A pilot study. Endoscopy. 2019 May;51(5):458-462
Bang B, Lee E, Maeng J, et al. Efficacy of a novel endoscopically deliverable mucoadhesive hemostatic powder in an acute gastric bleeding porcine model. PLoS One. 2019 Jun 11;14(6)e0216829
Park JS, Kim HK, Shin YW, et al. Novel hemostatic adhesive powder for nonvariceal upper gastrointestinal bleeding. Endoscopy International Open. 2019 Dec;7(12):E1763-E1767
J Shin et al. Efficacy of a novel hemostatic adhesive powder in patients with upper gastrointestinal tumor bleeding https://doi.org/10.1186/s12876-021-01611-0 Published